a1 wayanova (SYSTAT)
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a1 wayanova
A1 Wayanova, supplied by SYSTAT, used in various techniques. Bioz Stars score: 96/100, based on 10980 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/a1+wayanova/SigmaStat+v4%2E0/pm28232480-116-22-24
Average 96 stars, based on 10980 article reviews
A1 Wayanova, supplied by SYSTAT, used in various techniques. Bioz Stars score: 96/100, based on 10980 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/a1+wayanova/SigmaStat+v4%2E0/pm28232480-116-22-24
Average 96 stars, based on 10980 article reviews
a1 wayanova - by Bioz Stars,
2026-09
96/100 stars
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other:Article Title: Heat shock protein 27-derived atheroprotection involves reverse cholesterol transport that is dependent on GM-CSF to maintain ABCA1 and ABCG1 expression in ApoE -/- mice. Article Snippet: Recently, we demonstrated that heat shock protein (HSP)-27 is protective against the development of experimental atherosclerosis, reducing plaque cholesterol content by more than 30%.. Moreover, elevated HSP-27 levels arepredictive of relative freedomfromclinical cardiovascular events.HSP-27 signalingoccursvia the activation of NF-kB which induces a marked up-regulation in GM-CSF expression, a cytokine that is known to alter ABC transporters involved in reverse cholesterol transport (RCT).. Therefore, we hypothesized that HSP-27-derived GMCSFhas a potent role in impedingplaque formationbypromotingmacrophageRCTand sought to better characterize thispathway.TreatmentofTHP-1cells,RAW-Bluecells, andprimarymacrophageswithrecombinantHSP-27 resulted in NF-kB activation via TLR-4 and was inhibited by various pharmacologic blockers of this pathway. |